Comprehending the practical uses of chemical compounds is important in medicine and organic chemistry. One such compound is 4′-bromoacetanilide which possesses interesting properties and has unique applications. In this blog post, we focus on the most significant features of 4′-bromoacetanilide, especially its melting point which is crucial in assessing its refinement and ascertaining its numerous possible applications.
Students and researchers will find the details captivating while other enthusiasts will get to know more about the compound’s scientific aspects and debates surrounding it. Brace yourself and let’s explore why 4’-bromoacetanilide has become popular in many fields.
What is 4′-bromoacetanilide and its Product Information?
4′-Bromoacentanilide is an example of an organic molecule which finds use in pharmaceutical and chemical research. This compound is a derivative of acetanilide, containing an additional bromine substituent on the molecule. This compound is mostly known for its application as an intermediate in the synthesis of other compounds. Like most other organic substances, 4′-Bromoacetanilide has certain physical properties useful for analyzing its purity, including its well-defined melting point.
What is the Chemical Formula of 4-bromoacetanilide?
As with all other chemicals, 4-bromoacetanilide has a unique chemical formula which is C8H8BrNO. Based on this formula, one of the most important pieces of information is knowing that 4-bromoacetanilide contains 8 carbon atoms, 8 hydrogen, 1 bromine, 1 nitrogen, and 1 oxygen atom. The benzene ring contains the bromine atom, which is attached to the para position with respect to the acetamide group.
How is 4-bromoacetanilide Used in the Synthesis of Other Compounds?
One of the most important characteristics of 4-bromoacetanilide is the presence of functional groups and reactivity, making it a useful organic synthesis compound. This intermediate is employed in the construction of pharmaceutical compounds, agrochemicals, and dyes. Moreover, the bromine substitution present on the benzene ring makes 4-bromoacetanilide suitable for further substitution reactions, both nucleophilic and electrophilic, which enable the forming of complex molecular structures.
Take for example 4-bromoacetanilide; in pharmaceutical research, it acts as a precursor for the synthesis of several aniline derivatives which are important for the synthesis of some analgesic and antipyretic medicines. The fact that it can be acetylated and brominated makes it easier for researchers to design specific compounds.
More recently, its use in Suzuki coupling reactions has been noted, and these reactions are important for the synthesis of biaryl structures which are significant in medicinal chemistry and materials science. Experimental data suggest that Suzuki coupling of 4-bromoacetanilide with some boronic acids leads to good yield products, frequently over 90% yield with proper optimization.
Moreover, the hydrolysis of 4-bromoacetanilide gives 4-bromoaniline, which is important in the dye and pigment production industry. This illustrates its usefulness for industrial scale processes. All in all, the compound serves as a versatile scaffold in academic research and industrial endeavors.
What are the Key Properties of 4-bromoacetanilide?
4-bromoacetanilide is characterized by its molecular weight, melting point, solubility, appearance, and chemical stability.
| Key Property | Value |
|---|---|
| Molecular Wt. |
|
| Melting Pt. | 162-166°C |
| Solubility | Slight in water, soluble in solvents |
| Appearance | White crystalline solid |
| Stability | Stable under standard conditions |
How to Safely Handle 4′-bromoacetanilide: Safety Documentation?
It is critical to wear safety goggles, gloves, and lab coats while handling 4-bromoacetanilide to avoid contact with the substance. To prevent inhalation of vapors or dust, handle the compound in well-ventilated areas or under fume hoods. The 4-bromoacetanilide should be stored away from other chemicals in a cool, dry place. After using the compound, wash hands thoroughly, and ensure proper cleanup of all spills in accordance with chemical spill response protocols. For comprehensive safety measures, consult the 4-bromoacetanilide Safety Data Sheet (SDS) for instructions on risk management.
What are the safety measures for dealing with 4-bromoacetanilide?
As with any chemical, bromoacetanilide 4’s safety precautions must be handled with care in accordance with good chemical hygiene practices. Always ensure to don safety goggles, protective gloves, lab coats, and any other relevant PPE to avoid skin or eye contact. Avoid all exposure to harmful dust or fumes and conduct your work in properly ventilated areas or fume hoods. Avoid contact with any of the following: ingestion and inhalation of the compound and also refrain from eating, drinking, and smoking while in the work area. Ensure the compound is stored in labeled containers and kept in cool, dry places, away from sources of ignition or incompatible materials. In the event of a spill, follow chemical spill response guidelines and dispose of the waste in the appropriate manner. For more details concerning handling and disposal refer to the 4-bromoacetanilide SDS.
What Material Safety Information is Available for 4-bromoacetanilide?
The Safety Data Sheet (SDS) for 4-bromoacetanilide offers material safety information relevant to the compound. Its sections often include identification of the compound, hazard classification, handling instructions and storage, first-aid action steps, accidental release action steps, and disposal considerations. Leady and screened 4-bromoacetanilides pose major risks of bromoacetanilide 4. Its critical concern is the irritation of the skin, eyes, and the respiratory system. For that reason, personal protective equipment such as gloves, goggles and masks is needed while working with the compound. Besides, the SDS also outlines emergency procedures such as dealing with spills or exposure, and provides information on the compound’s stability and reactivity.
How to Determine the Melting Point of 4′-bromoacetanilide?
- Make sure the sample is dry and finely powdered for accuracy.
- Fill a capillary tube with a small amount of the sample, sealing one end.
- Insert the tube into the melting point apparatus.
- Observe the sample as you gradually increase the temperature.
- Take note of the temperatures at which the sample first becomes cloudy and then a clear liquid.
What Is the Melting Point Temperature Range?
4’-bromoacetanilide’s melting point is usually between 165°C and 168°C. This range is subject to some variation depending on the sample’s purity. A pure 4′-bromoacetanilide will often sharpened melting point; while contaminated or impure samples can depress or broaden the observed temperature range. The identity and purity of a compound, particularly in chemical syntheses or research, can be corroborated—and is critical to confirm—via melting point determination.
Why Is Melting Point Necessary In Chemical Analysis?
Analyzing the melting point is crucial during chemical analysis because it helps in determining identity and assessingatio purity. For instance, complete 4’-bromoacetanilide’s elementary form has a narrow range of 165 to 163 °C. However, any minor change to its composition will either decrease this range or increase it tremendously. This property is beneficial in allowing chemists to estimate the consistency and quality of the samples that are either synthesized or extracted. In terms of modern methods of chemical analysis, it is possible to measure these values with an advanced digital melting point apparatus that determines them precisely within ± 0.1 °C. Such tools can help researchers in identifying even the most minute contaminant quantites which were not possinle before.
As for other aspects of the melting point, it is crucial to compound storage as it defines shedding point which helps in determining compound stability. Moreover, in the field of material science or pharmaceutical, those compounds are easier to use as the tightly defined structure often makes them thermally robust. Additinally, chemists tend to validate their work by checking cross reference of melting points from trusted chemical databases as NIST Chemistry WebBook which helps verify compounds fast and easlyas well as ensure consistency. All of these enhance the reliability, accuracy with which chemical researches are conducted.
What are the Production and Property Aspects of 4′-bromoacetanilide?
4′-Bromoacetanilide is undergo the bromination of acetanilide in the introduction of bromine in the para position of the aromatic ring. The reaction usually takes place under controlled parameters for selective yield and by-product minimization.
As an intermediate in the synthesis of organic compounds such as dyes and pharmaceuticals, four bromoacetanilide holds pivotal importance. Its stability and reactivity defines its significance as a substrate in the field of chemical studies and industry.
How is 4-bromoacetanilide Production Conducted?
4′-Bromoacetanilide production undergoes the bromination reaction of acetanilide with bromine or N-bromosuccinimide (NBS). Selectivity is maintained at the para position of the aromatic ring. Process often employs solvents of glacial acetic acid which aids in dissolving the reactants for even reactions.
New focus has been placed on the Minimization of Production’s Environmental Effects Green Chemistry Practices. For example, some labs have substituted traditional solvents and reagents brominated with safer and more efficient water-based solvents. These advances enhance reaction efficiency and minimize the formation of dangerous by-products.
Optimized reaction parameters also provide data. In this case, maintaining the reaction temperature at 0ºC – 10ºC prevents side reactions while ensuring product purity. The yield of 4′-bromoacetanilide will vary between 70% to 90% based on a combination of factors such as reagents, conditions used, and method applied. This efficiency balance allows the method to be used at a laboratory-scale as well as for industrial purposes.
However, these are not the only applications for the compound’s characterization. Control within the precision must also be of high importance. heterocyclic compound purity characterization combined NMR and HPLC ensures that the structure meets defined benchmarks so that further processing can be done safely.
Changes in State With Variation in Temperature
As I understand, the straight change in substance properties persists with temperature variations. For instance, physical properties such as viscosity, density, and even solubility tend to either increase or decrease based on thermal energy input. Chemical stability is another property that may be affected whereby hot temperatures will cause some reactions to occur or disproportionate chemical compounds. Watching change is very critical for some applications in order to maintain optimal performance and safety.
Is 4′-bromoacetanilide Soluble in Common Solvents?
Indeed, although 4′-bromoacetanilide is sparingly soluble in water, it is more soluble in organic solvents including ethanol, methanol, and acetone. These solvents are used to dissolve such compounds because they can interact with both polar and nonpolar components of the molecule.
How Soluble is 4′-Bromoacetanilide in Water and Alcohol?
Available literature suggests that 4′-bromoacetanilide has only limited solubility in water. Its solubility in water at room temperature is approximately 0.2 g/L, only qualifies as sparingly soluble. The reason for this is its organic nature, which is lacking in nonpolar character. This diminishes interactions with water.
In contrast, 4′-bromoacetanilide is more soluble in the alcohols ethanol and methanol. Ethanol, as a moderately polar solvent, dissolves 4′-bromoacetanilide to a concentration of 10-20 g/L. Methanol, with its higher relative polarity, often shows these solubility results or slightly better. Alcohol solvents also tend to be more effective at higher temperatures, which works for instances where high concentrations of the drug are required.
This serves as a reminder of the relevance of working with the right solvent in carrying out certain chemical processes or reactions because in most cases, the compounds to be used are not soluble like 4’-bromoacetanilide.
What are the solubility characteristics in benzene, chloroform and ethyl acetate?
Due to differences in the degrees of solubility of 4’-bromoacetanilide in benzene, chloroform and ethyl acetate, it can be considered that the polarities of these solvents differ. As a nonpolar solvent, benzene will moderately dissolve 4‘-bromoacetanilide since the compound is not rich in functional groups polar in nature. Chloroform, being a bit more polar, usually increases solubility more because it interacts better with the compound’s bromine and amide groups. Furthermore, as a polar aprotic solvent, ethyl acetate usually has the highest solubility of 4’-bromoacetanilide out of the three due to dipole-dipole forces. It can support the compound’s polar regions and thus will show stronger solvation. These differences serve more testimony to the importance of the properties of the solvent in relation to the optimization of processes involving chemical 4’-bromoacetanilide.
Reference sources
- “Crystallization behaviour of polyamide 4 and its effect on melting point”
- Authors: Mingda Wang et al.
- Journal: Polymer
- Publication Date: December 1, 2023
- Key Findings: This study investigates the crystallization behavior of polyamide 4 and its impact on the melting point. The authors explore how different processing conditions affect the crystallization and melting characteristics of the polymer, which can provide insights into the melting behavior of similar organic compounds.
- Methodology: The research employs differential scanning calorimetry (DSC) to analyze the melting points and crystallization behavior under various conditions, providing a detailed understanding of the thermal properties of polyamide 4(Wang et al., 2023).
- “3D printing soft robots integrated with low-melting-point alloys”
- Authors: Liuchao Jin et al.
- Journal: Materials Science in Additive Manufacturing
- Publication Date: September 4, 2024
- Key Findings: This paper discusses the development of soft robots that utilize low-melting-point alloys (LMPAs) for actuation. The study highlights the energy-saving characteristics of these materials, which can change shape upon heating and cooling, thus providing insights into the practical applications of low-melting-point materials.
- Methodology: The authors describe a material extrusion additive manufacturing process to integrate LMPAs into soft robots, detailing the thermal cycling and the melting behavior of the alloys used(Jin et al., 2024).
- “Experiment and Molecular Dynamic Simulation on Interactions between 3,4-Bis(3-nitrofurazan-4-yl) Furoxan (DNTF) and Some Low-Melting-Point Explosives”
- Authors: Junming Yuan et al.
- Journal: Molecules
- Publication Date: August 1, 2024
- Key Findings: This study analyzes the compatibility and interactions between DNTF and various low-melting-point explosives. The findings indicate that DNTF exhibits good compatibility with several low-melting-point explosives, which could be relevant for understanding the melting behavior of similar compounds.
- Methodology: The research utilizes differential scanning calorimetry (DSC) and molecular dynamics simulations to assess the thermal properties and interactions of the compounds(Yuan et al., 2024).
Frequently Asked Questions (FAQs)
Q: What is the melting point of 4-bromoacetanilide?
A: The melting point of 4-bromoacetanilide is around 98 degrees celsius.
Q: What is the CAS number for 4-bromoacetanilide?
A: The CAS number for 4-bromoacetanilide is 103-88-8.
Q: Is 4-bromoacetanilide soluble in cold water?
A: 4-bromoacetanilide is only slightly soluble in cold water.
Q: Can 4-bromoacetanilide be used as an internal standard for phenylurea?
A: 4-bromoacetanilide can indeed be used as an internal standard for phenylurea and for the associated metabolic pathways.
Q: Is 4-bromoacetanilide soluble in alcohol?
A: 4-bromoacetanilide is indeed soluble in alcohol.
Q: Does 4-bromoacetanilide have any relation to triazine herbicides and their transformation products?
A: 4-Bromoacetanilide is employed in the assay of several phenylurea and triazine herbicides and their degradation products.
Q: Is 4-bromoacetanilide a product of Thermo Scientific Chemicals brand?
A: 4-bromoacetanilide is listed as part of the Thermo Scientific Chemicals product line.
Q: What is the boiling point of 4-bromoacetanilide?
A: The boiling point of 4-bromoacetanilide is not usually listed because it is mainly known by its melting point.
Q: Are there any applications of 4-bromoacetanilide in the determination of herbicides?
A: 4-bromoacetanilide serves in the determination of several phenylurea and triazine herbicides and their transformation products.
